- Title
- Liquid-based vs. conventional cytology on respiratory material (letter)
- Creator
- Zardawi, Ibrahim M.; Blight, Alison; Ling, Sharon; Braye, Stephen G.
- Relation
- Acta Cytologica Vol. 53, Issue 4, p. 481-483
- Relation
- http://www.acta-cytol.com/toc/auto_abstract.php?id=23130
- Publisher
- S. Karger AG
- Resource Type
- journal article
- Date
- 2009
- Description
- Respiratory cytology is of considerable diagnostic value in the evaluation of lung pathology, especially in cases in which it is difficult to obtain bronchoscopic biopsy material for histologic evaluation. However, respiratory cytology is highly operator dependent and suffers from low sensitivity. Due to nonuniformity of slide preparation and fixation, conventional smears (CS) are time consuming to screen. Specimen thickness, overlapping cellular material, obscuring inflammation and blood and air-drying artefacts result in poor cellular preservation. Liquid-based cytology (LBC), on the other hand, has the advantage of optimally preserving the cellular material, removing excess blood and inflammatory cells and producing a preparation with random distribution of the constituent cells. LBC has been around for more than a decade, and its role in gynecologic cytology is well established. The impact of LBC has been less obvious in the field of nongynecologic cytology. ThinPrep (TP) (Cytyc Corp., Marlborough, Massachusetts, U.S.A.) has been shown to correlate well with conventional preparations in fine needle aspirates (FNAs) and body fluids. Cell spread in a thin layer and removal of mucus, blood and inflammatory exudate have been the main advantages of TP. Better utilization of skilled cytotechnologists and streamline of the work flow in the laboratory are potential advantages of TP.
- Subject
- bronchial washing; liquid-based cytology; sputum
- Identifier
- uon:7129
- Identifier
- http://hdl.handle.net/1959.13/806481
- Identifier
- ISSN:0001-5547
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